A notable teacher, Mary McLeod Bethune founded a school for black girls in Florida.  This eventually became Bethune-Cookman College, where she served as the school's president until 1942.  Birthplace: Mayesville.  
Vice-president under John Quincy Adams and Andrew Jackson, John C. Calhoun also served other numerous cabinet positions, such as secretary of war and secretary of state.  He was a proponent of slavery.  Birthplace: Abbeville. 
Robert Mills was one of the earliest American architects.  He designed numerous governmental buildings.  His greatest achievement was the design of the Washington Monument.  Birthplace: Charleston.